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α cd44 neutralizing antibody  (Bio X Cell)

 
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    Structured Review

    Bio X Cell α cd44 neutralizing antibody
    A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of <t>CD44</t> between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).
    α Cd44 Neutralizing Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α cd44 neutralizing antibody/product/Bio X Cell
    Average 94 stars, based on 46 article reviews
    α cd44 neutralizing antibody - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Natural killer cells associate with epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment"

    Article Title: Natural killer cells associate with epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment

    Journal: bioRxiv

    doi: 10.1101/2024.05.23.593868

    A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of CD44 between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).
    Figure Legend Snippet: A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of CD44 between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).

    Techniques Used: Expressing

    A. Schematic for Transwell invasion assays. Average relative invasion + SEM of B. Donor NK #1 (n = 9), C. Donor NK #2 (n = 12), D. Donor NK #3 (n = 6), and E. Donor NK #4 (n = 10) upon CD44 neutralization. * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test. F. Schematic of spheroid invasion assay. G. Representative 20X immunofluorescence images of outlined (yellow) PANC-1 spheroids (pan-cytokeratin; red) embedded with NK cells (CD56; green), pointed out with white arrows, treated with or without α-CD44. Scale bar = 250 µm. H. Zoomed inset of NK cells in the α-CD44 treatment group in G (white box). Average number of NK cells per PANC-1 spheroid + SEM from I. Donor NK #1 (- α-CD44, n = 42; + α-CD44, n = 53), J. Donor NK #2 (- α-CD44, n = 43; + α-CD44, n = 29), and K. Donor NK #3 (- α-CD44, n = 47; + α-CD44, n = 27); n = # of spheroids analyzed; * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test.
    Figure Legend Snippet: A. Schematic for Transwell invasion assays. Average relative invasion + SEM of B. Donor NK #1 (n = 9), C. Donor NK #2 (n = 12), D. Donor NK #3 (n = 6), and E. Donor NK #4 (n = 10) upon CD44 neutralization. * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test. F. Schematic of spheroid invasion assay. G. Representative 20X immunofluorescence images of outlined (yellow) PANC-1 spheroids (pan-cytokeratin; red) embedded with NK cells (CD56; green), pointed out with white arrows, treated with or without α-CD44. Scale bar = 250 µm. H. Zoomed inset of NK cells in the α-CD44 treatment group in G (white box). Average number of NK cells per PANC-1 spheroid + SEM from I. Donor NK #1 (- α-CD44, n = 42; + α-CD44, n = 53), J. Donor NK #2 (- α-CD44, n = 43; + α-CD44, n = 29), and K. Donor NK #3 (- α-CD44, n = 47; + α-CD44, n = 27); n = # of spheroids analyzed; * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test.

    Techniques Used: Neutralization, Invasion Assay, Immunofluorescence



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    α cd44 neutralizing antibody  (Bio X Cell)
    94
    Bio X Cell α cd44 neutralizing antibody
    A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of <t>CD44</t> between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).
    α Cd44 Neutralizing Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/α cd44 neutralizing antibody/product/Bio X Cell
    Average 94 stars, based on 1 article reviews
    α cd44 neutralizing antibody - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of CD44 between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).

    Journal: bioRxiv

    Article Title: Natural killer cells associate with epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment

    doi: 10.1101/2024.05.23.593868

    Figure Lengend Snippet: A. Incoming and outgoing interaction strength for each cell population grouped by AdjNorm and PDAC disease states. B. Communication probabilities of signaling pathways targeting NK cells between AdjNorm and PDAC disease states as measured by information flow (pathway legend: pink = AdjNorm-specific, teal = PDAC-specific, black = equally specific). C. Significant ligand-receptor pairs from collagen, FN1, and laminin signaling pathways targeting NK cells upregulated in PDAC compared to AdjNorm. Violin plots showing differential expression of CD44 between PDAC (teal) and AdjNorm (pink) disease states in D. normal epithelial cells, E. malignant epithelial cells, F. fibroblasts, and G. NK cells (NS = not significant, ** P < 0.01, **** P < 0.0001, Bonferroni correction).

    Article Snippet: Donor NK cells were added to Transwells with or without an α-CD44 neutralizing antibody (clone IM7; Bio X Cell; C f = 10 µg/ml) and incubated for 4 hours (37°C).

    Techniques: Expressing

    A. Schematic for Transwell invasion assays. Average relative invasion + SEM of B. Donor NK #1 (n = 9), C. Donor NK #2 (n = 12), D. Donor NK #3 (n = 6), and E. Donor NK #4 (n = 10) upon CD44 neutralization. * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test. F. Schematic of spheroid invasion assay. G. Representative 20X immunofluorescence images of outlined (yellow) PANC-1 spheroids (pan-cytokeratin; red) embedded with NK cells (CD56; green), pointed out with white arrows, treated with or without α-CD44. Scale bar = 250 µm. H. Zoomed inset of NK cells in the α-CD44 treatment group in G (white box). Average number of NK cells per PANC-1 spheroid + SEM from I. Donor NK #1 (- α-CD44, n = 42; + α-CD44, n = 53), J. Donor NK #2 (- α-CD44, n = 43; + α-CD44, n = 29), and K. Donor NK #3 (- α-CD44, n = 47; + α-CD44, n = 27); n = # of spheroids analyzed; * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test.

    Journal: bioRxiv

    Article Title: Natural killer cells associate with epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment

    doi: 10.1101/2024.05.23.593868

    Figure Lengend Snippet: A. Schematic for Transwell invasion assays. Average relative invasion + SEM of B. Donor NK #1 (n = 9), C. Donor NK #2 (n = 12), D. Donor NK #3 (n = 6), and E. Donor NK #4 (n = 10) upon CD44 neutralization. * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test. F. Schematic of spheroid invasion assay. G. Representative 20X immunofluorescence images of outlined (yellow) PANC-1 spheroids (pan-cytokeratin; red) embedded with NK cells (CD56; green), pointed out with white arrows, treated with or without α-CD44. Scale bar = 250 µm. H. Zoomed inset of NK cells in the α-CD44 treatment group in G (white box). Average number of NK cells per PANC-1 spheroid + SEM from I. Donor NK #1 (- α-CD44, n = 42; + α-CD44, n = 53), J. Donor NK #2 (- α-CD44, n = 43; + α-CD44, n = 29), and K. Donor NK #3 (- α-CD44, n = 47; + α-CD44, n = 27); n = # of spheroids analyzed; * P < 0.05 as determined by Wilcoxon matched-pairs signed rank test.

    Article Snippet: Donor NK cells were added to Transwells with or without an α-CD44 neutralizing antibody (clone IM7; Bio X Cell; C f = 10 µg/ml) and incubated for 4 hours (37°C).

    Techniques: Neutralization, Invasion Assay, Immunofluorescence